I've only recently found that there are now Skeptics in the Pub meetings being organised in Lewes, at the Elephant and Castle, White Hill. The March 24 Meeting, featuring Simon Singh on Alternative Medicine is already sold out. There are meetings planned from April to August, but it looks as if it is necessary to book in advance.
There is also an established programme in Brighton. They meet at the Caroline of Brunswick, 39 Ditchling Road. The April 12 talk is by David Aaronovitch on Conspiracy Theories.
There are other Skeptics in the Pub groups all round the country, though not all are as active.